Antimicrobial Activity of Broth Fermented with Kombucha Colonies

The kombucha is a consortium of yeast and bacterias originally from China, and able to produce a fermented broth, which presents antimicrobial activity against some pathogenic microorganisms.

The goal of this work was to investigate the antimicrobial activity of fermented broth by kombucha colonies in the same condition used in a hospital in the Northeast of Brazil and to optimize the medium of kombucha growth.

The fermented growth was efficient against Microsporum canis (LM-828), Escherichia coli (CCT-0355) and Salmonella typhi (CCT-1511). The best conditions of inhibition against M. canis (> 32mm) and E. coli (16 mm) was observed at pH 4.0, 55% of commercial sugar and 0.10 g/l of MgSO4, and for S. typhi (32 mm) without MgSO4. 

The mPEG-PCL Copolymer for Selective Fermentation of Staphylococcus lugdunensis Against Candida parapsilosis in the Human Microbiome

The skin is colonized by a diverse array of microorganisms including bacteria and fungi. The skin microbiome is defined as the collection of all microbes that colonize the skin. Environments at various topographical areas of skin can affect the microbial colonization. The major bacterial-fungal populations colonizing human scalps have been characterized.

Furthermore, the dysbiosis of bacterial-fungal populations has been implicated in scalp dandruff, which presents as significant problems to large numbers of people. Dandruff scalps are associated with a higher abundance of Malassezia restricta and Staphylococcal species. The severity of dandruff can range from mild scale formation similar to dry skin to seborrheic dermatitis.

The impairment of proper hydration in skin barrier can result in the typical epidermal proliferation, keratinocyte differentiation and stratum corneum maturation, which may cause dandruff. Excessive secretion of the sebaceous gland also can underlie dandruff development. Besides dysfunction of the skin barrier and sebaceous gland, fungal/bacterial dysbiosis may be one of the factors that result in the progression of human dandruff.

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