Uric acid (UA) is the poorly soluble circulating end product
of purine nucleotide metabolism in human beings. Hyperuricemia, caused by
purine metabolism disorder or reduction in uric acid excretion is the most
important biochemical basis of gout. It is generally accepted that hyperuricemia
has also been shown to correlate with the cluster of metabolic disorders,
closely associate with the features of metabolic syndrome and chronic renal lesion.
Besides,
hyperuricemic patients are also at greater risk for evolving into many
conditions such as metabolic, cardiovascular, renal and many other
comorbidities, which collectively result in an increased mortality. Drugs such
as benzbromarone, probenecid, and allopurinol are usually used in the treatment
of hyperuricemia, However, these drugscan only be used to relieve the illness, long-term use of the drugs would
lead to side effects on liver and kidney. Epidemiological evidence has
indicated that diet may reduce the risk of chronic disease. Therefore, it is an
important aspect and an inevitable trend to make use of bioactive food
components to mitigate hyperuricemia.
Konjac glucomannan (KGM), a kind of excellent dietary fiber
polysaccharide, has been broadly used as food, food additive and traditional
Chinese medicine for a long history. It has been reported that KGM has several
valuable functions of healthcare and pharmacology, such as obesity-suppression,
tumor-suppression, as well as the treatment of cough, hernia, and skin
disorders. However, what worth mentioning is that no one studied the effect of
KGM on hyperuricemia before. In the preset study, rats were used as model
animals to investigate
the effect and potential mechanisms of KGM on hyperuricemia, and the effect
of KGM on renal histological lesion was also analyzed.
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