The present study was conducted to elucidate
the antioxidant capacity of green tea (Camellia sinensis) extract against
Tamoxifen citrate-induced liver injury. Four groups containing ten female
Wister rats each were selected: Group I, served as control group, Group II,
permitted Green Tea Extract (1.5% w/v in water) as the sole drinking fluid,
Group III, injured by intraperitoneal
injection of Tamoxefin (45 mg/ Kg/day) for 7 successive days and Group IV,
permitted green tea extract as a sole source of drinking water (1.5% w/v in
water) 4 days prior and 14 days after Tamxifen-intoxication (45 mg/Kg/day for 7
successive days).
Hepatic oxidative damage was observed in
Tamoxefin treated rats as evidenced via augmentation in liver lipid
peroxidation as well as depletion in liver antioxidant enzymes; catalase, superoxide
dismutase and glutathione peroxidase with highly degeneration and necrosis of
the hepatocytes.
Histopathological studies of liver treated
with Tamoxefin revealed that supplementation of green tea extract resulted in
mild degeneration and necrosis of the hepatocytes.
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