Tuesday, 7 March 2017

Bioprospecting and Drug Development, Parameters for a Rational Search and Validation of Biodiversity

Natural products (NP) are defined as all substances produced by living organisms that include secondary metabolites defined as compounds produced by biological processes that are not necessary for primary or energy metabolism, but are important for ecological fitness. These molecules have been developed by the evolutionary pressure on biosynthetic pathways which results in a large and exuberant chemical diversity with potent biological activity with high impact on chemical biology and pharmaceutical industry.

NPs are obtained from biological diversity defined in Article 2 of the Convention on Biological Diversity as “The variability among living organisms from all sources including, inter alia, terrestrial, marine, and other aquatic ecosystems and the ecological complexes of which they are part; this includes diversity within species, between species and of ecosystems”.

The prospective study of biodiversity looking for applications in agriculture, industry and medicine; known as bioprospecting, is defined as the process of looking for in natural sources new promising genetic resources and bioactive compounds as well as organisms with biotechnological uses.

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