In early times,
scientists considered antibiotic resistance in terms of adaptation to the toxic
agents. For instance, Ehrlich worked on development of p-rosaniline resistance
to Trypanosoma brucei as early as 1904.
The resistance
was observed during the treatment of trypanosome infections as the organisms
emerged that were resistant to p-rosaniline. The drug inactivation was also
discovered early as well.
In 1919,
Neuschlosz reported Paramecium caudatum resistance to quinine and a dye that
acquired the ability to destroy the toxic agent.
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