Development of
new technologies for Biological Warfare Agents (BWA) stand-off detection
implies several safeties, logistic and economic drawbacks
that involve production of different highly virulent bacteria and viruses,
their isolation and characterization under adequate bio-containment and sample
preparation for each agent to evaluate the testing method.
In order to
overcome these difficulties most of the research activities and tests reported
so far, are performed using simulants: Biological Agents (BA) which are
phylogenetically or structurally related to BWA.
The use of the
simulants (BWA-S) show, however, some limitations: they can share some of the
properties of the biological warfare agents but have different antigens,
proteome and genome.
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