Tuesday, 4 October 2016

Protective Effect of Trigonella foenum-graecum and Foeniculum vulgare Mature Leaf Against t-BHP Induced Toxicity in Primary Rat Hepatocytes

Liver is the pivotal organ in the human body and has intense metabolic activities. It is involved with almost all the biochemical pathways related to growth, fight against disease, nutrient supply and energy provision.

Primary Rat Hepatocytes
Thus, to maintain a healthy liver in human is of great importance for the normal metabolism of the body. Reactive oxygen species (ROS), the by-products of cellular metabolism, can damage the macromolecules like lipid, nucleic acid, protein which may leads to various diseases, like heart disease, cardiovascular disease, cancer, diabetes, Alzheimer’s disease, cataracts and age related functional disorders.


Exogenous and endogenous harmful chemicals are processed by the liver to be eliminated from the body. There is less availability of such therapy in western medicines which can cure these diseases without side effects. In recent year, there has been a global trend towards the use of natural phytochemicals present in fruits, vegetables, oil seed and herbs as antioxidant and functional food.

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